A.B. in Biology, Harvard University
A.M. in Biology, Princeton University
Ph.D. in Biology, Princeton University
Leslie earned an A.B. in Biology at Harvard University as a John Harvard scholar, where he trained with Nicole Francis to uncover sequence features underlying polycomb group protein activity. Under her tutelage, Leslie gained a lasting appreciation for biochemical approaches to understand protein function. He then completed an A.M. and Ph.D. in Biology from Princeton University with Laura Landweber and Tom Muir as a Petrie fellow, where he developed methods for assembling synthetic chromosomes with custom epigenetic modifications. Through genomics and biochemical fractionation approaches, he identified a novel DNA methyltransferase complex that is homologous to the RNA m6A methyltransferase, METTL3/14. Leslie then embarked on a short postdoctoral stint with Sam Sternberg at Columbia University, where he used genomic, structural, and biochemical approaches to study CRISPR-Cas systems that mediate RNA-guided DNA integration. Leslie then pursued a career in industry, joining Illumina to lead a research group for developing novel epigenetics assays.
Senior Research Fellow
Liu Pei graduated from Mount Holyoke College with a B.A. in Biochemistry and worked in Professor Kathryn McMenimen’s lab on biochemical characterization of heat shock protein HSP27. She then spent a year in Dr. Su Seong Lee’s lab at Institute of Bioengineering and Nanotechnology, A*STAR, to design and characterize novel scaffolds for glycomimetics. She obtained her Ph.D. in Chemistry from UC Berkeley with Professor Evan Miller, where she developed strategies to genetically target fluorescent dyes to detect membrane potential changes in specific cells of interest. Her undergraduate and graduate studies were supported by the A*STAR NSS-BS/PhD scholarships. She received her postdoctoral training with Professor Katherine Ferrara and Professor Stanley Qi at Stanford University, working on an interdisciplinary project to use CRISPR/Cas for ultrasound-mediated genome engineering.
In the Beh lab, Liu Pei is interested in designing and applying CRISPR/Cas-based tools for precise modifications of mRNA and studying these modifications in vitro and in vivo.
B.S. (Honours) in Life Sciences, with specialisation in Biomedical Science (BMS); Highest Distinction; National University of Singapore
Aye Sandy Bo
B.S. in Molecular Biology, Genetics and Microbiology, University of Sydney
Sandy did her Bachelor of Medical Sciences with double major in Molecular Biology and Genetics and Microbiology at the University of Sydney. She did her Diploma in Molecular Biotechnology at Ngee Ann Polytechnic. Through multiple projects, she developed a passion for genetics. Genetic material is the information centre of life and through extensive research, she hopes to uncover key aspects of genetic modifications that could be used as therapeutics in the future. Outside of science, she enjoys baking and spending time in nature.
B.A. in Natural Sciences (Pathology), University of Cambridge
In 2022, Nicole completed the International Baccalaureate Diploma Programme and graduated from Anglo-Chinese School (Independent). As part of the programme, she wrote her Extended Essay in Biology, investigating the antifungal properties of natural dyes extracted from plants. Under the guidance of Dr. Jinhyuk Fred Chung, Chief Scientific Officer at Xylonix.io, she also studied how DNA repair mutations altered blood cancer sensitivity to chemotherapeutic drugs. Nicole hopes to study Medicine at university and eventually become a clinician-scientist, pursuing both clinical practice and scientific research.
Eunice graduated from the National Junior College Integrated Programme in 2022. She took up H3 Research, and generated novel iron and gold DNAzymes under the guidance of Dr. Liu Zhennan from the Institute of Sustainability for Chemicals, Energy and Environment, A*STAR. Eunice also participated in an international research exchange programme with students from Mahidol Wittayanusorn School, Thailand, during which she studied inexpensive methods to extract lipases from various seeds and characterised these lipases. In the future, Eunice endeavours to study Biology, and pursue a career in genetics research.