Hoffmann, F.*, Kim, M.*, Beh, L.Y.*, Wang, J., Vo, P.L.H., Gelsinger, D.R., Acree, C., Mohabir, J.T., Fernández, I.S., Sternberg, S.H. Selective recruitment of the AAA+ ATPase TnsC increases the fidelity of Type I-F CRISPR RNA-guided transposition.
*Co-first author

Nature 609, 384-393 (2022).

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Klompe, S.E., Jaber, N., Beh, L.Y., Mohabir, J.T., Sternberg, S.H. Evolutionary and mechanistic diversity of Type I-F CRISPR-associated transposons.

Mol Cell 82, 616-628 (2022).

Beh, L.Y., Debelouchina, G.T., Clay, D.M., Thompson, R.E., Lindblad, K.A., Hutton, E.R., Bracht, J.R.,

177,1781-96 (2019). Cover story.

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Wojcik, F., Dann, G.P., Beh, L.Y., Debelouchina, G.T., Hofmann, R., Muir, T.W. Functional crosstalk between histone H2B ubiquitylation and H2A modifications and variants.

Nat Commun. 9, 1394 (2018).

Chen, X., Jung, S., Beh, L.Y., Eddy, S.R., Landweber, L.F. Combinatorial DNA rearrangement facilitates the origin of new genes in ciliates.

Genome Biol Evol. 7, 2859-70 (2015).

Beh, L.Y., Müller, M.M., Muir, T.W., Kaplan, N., Landweber, L.F. DNA-guided establishment of nucleosome patterns within coding regions of a eukaryotic genome.

Genome Res. 25, 1727-38 (2015).

Beh, L.Y., Colwell, L.J., Francis, N.J. A core subunit of Polycomb repressive complex 1 is broadly conserved in function but not primary sequence.

Proc Natl Acad Sci U S A 109, E1063-71 (2012).